Makoto Bonkobara Selected Research

Histiocytic Sarcoma

3/2022	Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma.
6/2020	Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099.
5/2020	Nimustine Treatment of 11 Cases of Canine Histiocytic Sarcoma.
6/2019	Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells.
6/2013	Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells.
9/2007	Comparison of dendritic cell-mediated immune responses among canine malignant cells.
12/2006	Establishment and biological characterization of canine histiocytic sarcoma cell lines.

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Makoto Bonkobara Research Topics

Disease

15	Neoplasms (Cancer) 04/2021 - 11/2006
7	Histiocytic Sarcoma 03/2022 - 12/2006
3	Melanoma (Melanoma, Malignant) 04/2021 - 01/2008
3	Neoplasm Metastasis (Metastasis) 02/2020 - 07/2012
3	Prostatic Neoplasms (Prostate Cancer) 06/2017 - 11/2015
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2021 - 09/2007
2	Mastocytosis 12/2015 - 01/2010
2	Lymphoma (Lymphomas) 02/2007 - 06/2005
1	Neutropenia 05/2020
1	Carcinoma (Carcinomatosis) 01/2020
1	Reoviridae Infections 06/2019
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2017
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/2017
1	Hypereosinophilic Syndrome (Loeffler Endocarditis) 08/2015
1	Breast Neoplasms (Breast Cancer) 01/2015
1	Hypercholesterolemia 12/2014
1	Carcinogenesis 10/2013
1	Lymphatic Metastasis 07/2011
1	Lymphocytosis 03/2009
1	Hypersensitivity (Allergy) 01/2008
1	B-Cell Leukemia (Leukemia, B Cell) 09/2007
1	Proteinuria 07/2007
1	Leukemia 02/2007
1	T-Cell Lymphoma (Lymphoma, T Cell) 02/2007
1	Neuroblastoma 01/2006
1	Body Weight (Weight, Body) 09/2002

Drug/Important Bio-Agent (IBA)

8	Imatinib Mesylate (Gleevec)FDA Link 10/2017 - 11/2006
3	VimentinIBA 01/2017 - 12/2006
2	SHP099IBA 03/2022 - 06/2020
2	Messenger RNA (mRNA)IBA 01/2020 - 01/2006
2	Androgen Receptors (Androgen Receptor)IBA 06/2017 - 11/2015
2	AndrogensIBA 06/2017 - 11/2015
2	Phosphotransferases (Kinase)IBA 06/2017 - 11/2006
2	Proteins (Proteins, Gene)FDA Link 11/2015 - 07/2007
2	Amino Acids FDA Link 07/2012 - 07/2011
2	Keratins (Keratin)IBA 08/2011 - 12/2006
2	Tyrosine Kinase InhibitorsIBA 07/2011 - 11/2006
2	keyhole-limpet hemocyanin (keyhole limpet hemocyanin)IBA 01/2008 - 09/2007
1	LigandsIBA 04/2021
1	Therapeutic UsesIBA 04/2021
1	sepantroniumIBA 03/2021
1	SurvivinIBA 03/2021
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 06/2020
1	NimustineIBA 05/2020
1	Vinblastine (Vinblastine Sulfate)FDA Link 02/2020
1	masitinibIBA 02/2020
1	CCR4 ReceptorsIBA 01/2020
1	Chemokine CCL17IBA 01/2020
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2020
1	Interferon Type IIBA 06/2019
1	MicroRNAs (MicroRNA)IBA 04/2017
1	N-cyclopropyl adenosine-5'-carboxamide (CPCA)IBA 04/2017
1	Cadherins (E-Cadherin)IBA 01/2017
1	Hematoxylin (Haematoxylon)IBA 01/2017
1	Coloring Agents (Dyes)IBA 01/2017
1	Chromogranin AIBA 01/2017
1	CAM 5.2 antigenIBA 01/2017
1	Carcinoembryonic AntigenIBA 01/2017
1	Phosphotungstic Acid (Acid, Phosphotungstic)IBA 01/2017
1	Adenosine Triphosphatases (ATPase)IBA 01/2017
1	Glutamine (L-Glutamine)FDA Link 11/2015
1	Rad51 RecombinaseIBA 01/2015
1	CholesterolIBA 12/2014
1	N 30IBA 12/2014
1	Proteasome InhibitorsIBA 12/2013
1	Bortezomib (Velcade)FDA Link 12/2013
1	Growth InhibitorsIBA 06/2013
1	Dasatinib (BMS 354825)FDA Link 06/2013
1	Complementary DNA (cDNA)IBA 07/2012
1	DesminIBA 08/2011
1	Immunoglobulin D (IgD)IBA 01/2010
1	AntigensIBA 03/2009
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 02/2007
1	naphthylbutyrate esteraseIBA 12/2006
1	Muramidase (Lysozyme)IBA 12/2006
1	Biological ProductsIBA 12/2006
1	Indicators and Reagents (Reagents)IBA 06/2005
1	EnzymesIBA 06/2005
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2005
1	Glucose (Dextrose)FDA LinkGeneric 06/2005
1	Pyruvate KinaseIBA 06/2005
1	Malate Dehydrogenase (Dehydrogenase, Malate)IBA 06/2005
1	Insulin-Like Growth Factor I (IGF-1)IBA 09/2002

Therapy/Procedure

9	Therapeutics 04/2021 - 11/2006
2	Immunotherapy 01/2020 - 09/2007